New medicine for the treatment of women with the risk of preterm birth
Indomethacin, one of the traditional drugs used to prevent preterm birth, inhibits the enzyme cyclooxygenase, which plays a key role in the development of premature birth. Not long ago, at the same time several research groups (including a group from the University of Washington) found that women with preterm labor have abnormally high levels of COX izoenzymes, only one, and exactly cyclooxygenase-2. Therefore, researchers hypothesized that a specific inhibitor of cyclooxygenase – 2 generic Celebrex may be effective in preventing preterm delivery with the fewest side effects.
24 women aged over 18 who have a birth on the age of 24 to 34 weeks’ gestation, received Celebrex or Indomethacin. All patients were randomized and included in the first group treated with Indomethacin, a second group treated with generic Celebrex. The health of mother and fetus before birth has been carefully studied.
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